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Muscle, Ligaments and Tendons Journal

Stem cell research and clinical development in tendon repair

Review article, 204 - 211
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Abstract
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Stem cells are one of the most fascinating areas in regenerative medicine today. They play a crucial role in development and regeneration and are defined as cells that continuously reproduce themselves while maintaining the ability to differentiate into various cell types. Stem cells are found at all developmental stages, from embryonic stem cells (ESCs) which differentiate into all cell types, to adult stem cells (ASCs) which are responsible for tissue regeneration. Studies using animal models have shown promising results following cell therapy for induced injury in musculoskeletal system, including tendon healing, but the results can be variable. Alternative sources for cell therapy in tendon pathology may include ESCs, ASCs (bone marrow, adipose tissue or tendon derived stem cells) or induced pluripotent stem cells (iPSCs). While ethical and safety concerns currently forbid clinical application of ESCs and iPSCs, initial clinical trials with ASCs are promising.

Vol. 7 (No. 1) 2017 January/March

  1. I.S.Mu.L.T. first-time patellar dislocation guidelines
    Vetrano M., Oliva F., Bisicchia S., Bossa M., De Carli A., Di Lorenzo L., Erroi D., Forte A., Foti C., Frizziero A., Gasparre G., Giai Via A., Innocenti B., Longo U.G., Mahmoud A., Masiero S., Mazza D., Natali S., Notarangelo C., Osti L., Padulo J., Pellicciari L., Perroni F., Piccirilli E., Ramponi C., Salvatore G., Schiavone Panni A., Suarez T., Tarantino U., Vittadini F., Vulpiani M.C., Ferretti A., Maffulli N.
    doi: 10.11138/mltj/2017.7.1.001
  2. Combined supplementation of ascorbic acid and thyroid hormone T3 affects tenocyte proliferation. The effect of ascorbic acid in the production of nitric oxide
    Di Giacomo V., Berardocco M., Gallorini M., Oliva F., Colosimo A., Cataldi A., Maffulli N., Berardi A.C.
    doi: 10.11138/mltj/2017.7.1.011
  3. Arthroscopic trans-osseous rotator cuff repair
    Chillemi C., Mantovani M.
    doi: 10.11138/mltj/2017.7.1.019
  4. Computerized tomographic assessment and clinical evaluation in shoulder instability treated with the Latarjet-Patte procedure using one screw and washer
    Cautiero F., Russo R., Di Pietto F., Sabino G.
    doi: 10.11138/mltj/2017.7.1.026
  5. Pre-operative corticosteroid injections improve functional outcomes in patients undergoing arthroscopic repair of high-grade partial-thickness rotator cuff tears
    Donohue N.K., Prisco A.R., Grindel S.I.
    doi: 10.11138/mltj/2017.7.1.034
  6. Functional treatment in rotator cuff tears: is it safe and effective? A retrospective comparison with surgical treatment
    De Carli A., Fabbri M., Lanzetti R.M., Ciompi A., Gaj E., Beccarini G., Vetrano M., Ferretti A.
    doi: 10.11138/mltj/2017.7.1.040
  7. Conservative, minimally invasive and open surgical repair for management of acute ruptures of the Achilles tendon: a clinical and functional retrospective study
    Maffulli G., Del Buono A., Richards P., Oliva F., Maffulli N.
    doi: 10.11138/mltj/2017.7.1.046
  8. Intratendinous tears of the Achilles tendon - a new pathology? Analysis of a large 4-year cohort
    Chan O., Morton S., Pritchard M., Parkes T., Malliaras P., Crisp T., Padhiar N., Maffulli N., King J., Morrisey D.
    doi: 10.11138/mltj/2017.7.1.053
  9. Morphometric evaluation of human tendocalcaneus: a cadaveric study of south indian male population
    Kumar N., Aithal A.P., Nayak S.B., Patil J-, Padavinangadi A., Ray B.B.
    doi: 10.11138/mltj/2017.7.1.062
  10. Activity level recovery after acute Achilles tendon rupture surgically repaired: a series of 29 patients with a mean follow-up of 46 months
    Zayni R., Coursier R., Zakaria M., Desrousseaux J-F, Cordonnier D., Polveche G.
    doi: 10.11138/mltj/2017.7.1.069
  11. Outcomes of prolotherapy for intra-tendinous Achilles tears: a case series
    Chan O., Havard B., Morton S., Pritchard M., Maffulli N., Crisp T., Padhiar N., Perry J.D., King J., Morrissey D.
    doi: 10.11138/mltj/2017.7.1.078
  12. Topical polidocanol application in combination with static stretching in tendinopathies: a prospective pilot study
    Gatz M., Schrading S., Dirrichs T., Tingart M., Rath B., Kuhl C., Quack V.
    doi: 10.11138/mltj/2017.7.1.088
  13. Conservative treatment for Insertional Achilles Tendinopathy: platelet-rich plasma and focused shock waves. A retrospective study
    Erroi D., Sigona M., Suarez T., Trischitta D., Pavan A., Vulpiani M.C., Vetrano M.
    doi: 10.11138/mltj/2017.7.1.098
  14. Plantar fasciitis in athletes: diagnostic and treatment strategies. A systematic review
    Petraglia F., Ramazzina I., Costantino C.
    doi: 10.11138/mltj/2017.7.1.107
  15. Comparison of dynamic postural stability scores between athletes with and without chronic ankle instability during lateral jump landing
    Shiravi Z., Shadmehr A., Talebian Moghadam S., Moghadam B.A.
    doi: 10.11138/mltj/2017.7.1.119
  16. The influence of muscle-tendon forces on ACL loading during jump landing: a systematic review
    Oberhofer K., Nasab S.H.H., Schütz P., Postolka B., Snedeker J.G., Taylor W.R., List R.
    doi: 10.11138/mltj/2017.7.1.125
  17. Effects of the menstrual cycle on lower-limb biomechanics, neuromuscular control, and anterior cruciate ligament injury risk: a systematic review
    Balachandar V., Marciniak J.-L., Wall O., Balachandar C.
    doi: 10.11138/mltj/2017.7.1.136
  18. Semitendinosus muscle architecture during maximum isometric contractions in individuals with anterior cruciate ligament reconstruction and controls
    Karagiannidis E., Kellis E., Galanis N., Vasilios B.
    doi: 10.11138/mltj/2017.7.1.147
  19. Chondrocytes treated with different shock wave devices
    Notarnicola A., Iannone F., Maccagnano G., Lacarpia N., Bizzoca D., Moretti B.
    doi: 10.11138/mltj/2017.7.1.152
  20. Ipsilateral hamstring tendon graft reconstruction for chronic patellar tendon ruptures: surgical technique
    Maffulli N., Del Buono A., Oliva F.
    doi: 10.11138/mltj/2017.7.1.157
  21. Assessment of different fitting methods for in-vivo bi-component T2* analysis of human patellar tendon in magnetic resonance imaging
    Liu F., Kijowski R.
    doi: 10.11138/mltj/2017.7.1.163
  22. Muscle fatigue in participants of indoor cycling
    de Melo dos Santos R., Costa e Costa F., Sepeda Saraiva T., Callegari B.
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  23. The influence of playing surface on injury risk in italian elite rugby players
    Lanzetti R.M., Lupariello D., Venditto T., Rota P., Guzzini M., Vadalà A., Rota A., Ferretti A.
    doi: 10.11138/mltj/2017.7.1.180
  24. Does combined strength training and local vibration improve isometric maximum force? A pilot study
    Goebel R., Haddad M., Kleinöder H., Yue Z., Heinen T., Mester J.
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  25. Ultrasound measures of tendon thickness: Intra-rater, Inter-rater and Inter-machine reliability
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  26. PTX3: a new mediator of bone metabolism and osteoporosis
    Tarantino U., Feola M., Celi M., Scimeca M.
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