Cic edizioni internazionali
Muscle, Ligaments and Tendons Journal

Simvastatin does not adversely affect Achilles tendon properties in a diet induced hypercholesterolemia rat model

Original Article, 199 - 205
doi: 10.11138/mltj/2018.8.2.199
Tag this article
Abstract
Full text PDF
Introduction: Hypercholesterolemia affects a third of adults in the United States and is commonly managed with statins. While statins provide proven cardiovascular benefits, their effect on the musculoskeletal system has been understudied.
The purpose of this study was to investigate the effects of statins on Achilles tendons of diet induced hypercholesterolemic rats.
Methods: Thirty adult male Sprague-Dawley rats were assigned to three groups: control (CTL, n=10), high cholesterol (HC, n = 10), and high cholesterol with statin (HC+S, n = 10). CTL was fed normal chow, while HC and HC+S were fed high cholesterol chow. H +S received simvastatin during the final 3 months, with all animals sacrificed 9 months after the study was initiated, followed by biomechanical testing and histological analysis.
Results: HC Achilles demonstrated increased stiffness as compared to both CTL and HC+S.
Histological analysis revealed trends toward increased cellularity in HC as compared to both CTL and HC+S. Both stiffness and cellularity exhibited a potential return to baseline effect with statin treatment, with no differences observed between CTL and HC+S.
Conclusions: While we were unable to determine conclusive therapeutic effects of statins, results support that statins may not have detrimental effects on Achilles tendon health when prescribed to hypercholesterolemic individuals.
Level of Evidence: Not applicable, this is a basic science study.

Vol. 8 (No. 4) 2018 October/December

  1. Chondrocalcinosis: a morphofunctional study of crystal deposition in mechanically stressed shoulder soft tissues
    Burini D., Salucci S., Fardetti F., Beccarini A., Calvisi V., Gobbi P., Falcieri E., Curzi D.
    doi: 10.11138/mltj/2018.8.4.465
  2. Functional hyper-extension deficit of the knee and patellar dimple sign in patellofemoral pain syndrome. A preliminary study
    Kaya D., Aksahin E., Doral M.N.
    doi: 10.11138/mltj/2018.8.4.473
  3. The triple F knot: a sliding-locking arthroscopic knot
    Spezia F., Franceschetti E., Franceschi F., Maffulli N., Oliva F.
    doi: 10.11138/mltj/2018.8.4.477
  4. MRI scans do not accurately predict hamstring graft diameter for ACL reconstruction
    Ricci P., Cullen C., Imalingat H., Sergeant J.C., Jain N.
    doi: 10.11138/mltj/2018.8.4.482
  5. Treating Haglund's Deformity with percutaneous Achilles tendon decompression: a case series
    Sergio F., Catani O., Fusini F., Langella F., Cautiero G., Ponzo I., Zanchini F.
    doi: 10.11138/mltj/2018.8.4.488
  6. Structured training volume in early adolescence: a risk factor for femoroacetabular impingement?
    Mullins K., Hanlon M., Carton P.
    doi: 10.11138/mltj/2018.8.4.495
  7. Relationship between anthropometric characteristics and playing position in youth soccer
    Notarnicola A., Maccagnano G., Chierico A., Tafuri S., Moretti B.
    doi: 10.11138/mltj/2018.8.4.502
  8. Posture and scapular dyskinesis in young bowed string instrumental musicians
    Frizziero A., Gasparre G., Corvo S., Gamberini J., Finotti P., Masiero S., Maffulli N.
    doi: 10.11138/mltj/2018.8.4.507
  9. Shoulder external/internal rotation peak torques ratio side-asymmetry, mean work and power ratios balance worsening due to different fatigue resistance of the rotator muscles in male handball players
    Pontaga I.
    doi: 10.11138/mltj/2018.8.4.513
  10. Does TRX training induce similar effects to crossfit? Study on the variation of body fat mass, endurance and explosive force
    Notarnicola A., Salatino G., Napoletano P., Monno A., Moretti B., Tafuri S.
    doi: 10.11138/mltj/2018.8.4.520
  11. The therapeutic effects of manipulation technique on sacroiliac joint dysfunction in young women
    Ashraf V., Shadmehr A., Moghadam B.A., Olyaei G., Reza Hadian M., Khazaeipour Z.
    doi: 10.11138/mltj/2018.8.4.526
  12. Changes of joint position sense in responses to upper trapezius muscle fatigue in subclinical myofascial pain syndrome participants versus healthy control
    Roya M., Gholam Reza O., Azadeh S., Reza H.M., Saeed T.M.
    doi: 10.11138/mltj/2018.8.4.534
  13. Extruded collagen fibres and biphasic collagen sponge for rotator cuff tendon repair application: an ovine in vitro study
    Zafar A., Rushton N.
    doi: 10.11138/mltj/2018.8.4.544
  14. The comparison of dynamic postural control and muscle activity in time domain in athletes with and without chronic ankle instability
    Fereydounnia S., Shadmehr A., Talebian Moghadam S., Olyaei G., Jalaie S., Shiravi Z., Salemi S.
    doi: 10.11138/mltj/2018.8.4.552
Last Viewed articles: la lista degli ultimi x visitati.
  1. Simvastatin does not adversely affect Achilles tendon properties in a diet induced hypercholesterolemia rat model
    Choi D.S., Shetye S.S., Tucker J.J., Huegel J., Soslowsky L.J.
    doi: 10.11138/mltj/2018.8.2.199
credits