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Muscle, Ligaments and Tendons Journal

Muscular injuries after tendon rupture in the rotator cuff of animal models. Systematic review

Original Article, 261 - 275
doi: 10.11138/mltj/2018.8.2.261
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Abstract
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Introduction: Atrophy, fatty infiltration and fibrosis are irreversible changes of the muscle after chronic retraction of a torn tendon. These changes result in further loss of function and are prognostic factors for worse clinical outcomes after surgical repair, making such approach ineffective.
Currently, there is no clinical treatment to reverse this degenerative condition. This review addresses the findings of experimental studies in the context of the molecular regulation and the cellular origin of the local fibro/adipogenic progenitors and satellite cells.
Methods: We systematically reviewed studies on animal models of muscular degeneration after lesion of the tendons of the rotator cuff. We used
PubMed as data source. Eligibility criteria were animal models assessing the degeneration of rotator cuff muscles after tendon injury or repair.
The articles were reviewed for experimental methodology of the lesion, control group and timing of repair.
Results: The experimental studies addressing muscle-tendon retraction have reproduced and described muscular changes at the macroscopic, histologic, biochemical and genetic level. With the aim to improve this condition, some possible surgical and pharmacological approaches have
been investigated.
Conclusion: Animal models for muscular degeneration after rotator cuff tears have been well established and described. The next challenge is the achievement of a therapeutic target that could be transferred to the clinical setting. Level of evidence: Not applicable.

Vol. 8 (No. 4) 2018 October/December

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