Cic edizioni internazionali
Muscle, Ligaments and Tendons Journal

Stem cell research and clinical development in tendon repair

Review article, 204 - 211
Tag this article
Abstract
Full text PDF
Stem cells are one of the most fascinating areas in regenerative medicine today. They play a crucial role in development and regeneration and are defined as cells that continuously reproduce themselves while maintaining the ability to differentiate into various cell types. Stem cells are found at all developmental stages, from embryonic stem cells (ESCs) which differentiate into all cell types, to adult stem cells (ASCs) which are responsible for tissue regeneration. Studies using animal models have shown promising results following cell therapy for induced injury in musculoskeletal system, including tendon healing, but the results can be variable. Alternative sources for cell therapy in tendon pathology may include ESCs, ASCs (bone marrow, adipose tissue or tendon derived stem cells) or induced pluripotent stem cells (iPSCs). While ethical and safety concerns currently forbid clinical application of ESCs and iPSCs, initial clinical trials with ASCs are promising.

Vol. 7 (No. 2) 2017 April/June

  1. Knocking-out matrix metalloproteinase-13 exacerbates rotator cuff muscle fatty infiltration
    Liu X., Ravishankar B., Ning A., Liu M., Kim H.T., Feeley B.T.
  2. Hyaluronic acid increases tendon derived cell viability and proliferation in vitro: comparative study of two different hyaluronic acid preparations by molecular weight
    Gallorini M., Berardi A.C., Berardocco M., Gissi C., Maffulli N., Cataldi A., Oliva F.
  3. Lactoferrin and parathyroid hormone are not harmful to primary tenocytes in vitro, but PDGF may be
    Musson D.S., Tay M.L., Chhana A., Pool B., Coleman B, Naot D., Cornish J.
  4. Cox-2 inhibition and the composition of inflammatory cell populations during early and mid-time tendon healing
    Blomgran P., Blomgran R., Ernerudh J., Aspenberg P.
  5. How to evaluate bone tunnel widening after ACL reconstruction - a critical review
    de Beus J.M., Koch J. EJ, Hirschmann A., Hirschmann M.T.
  6. Minimally invasive anatomic reconstruction of the anterolateral ligament with ipsilateral gracilis tendon
    Trinchese G.F., Oliva F., Maffulli N.
  7. Arthroscopic ACL reconstruction using patellar bone tendon autograft and Rigidfix fixation - A midterm functional outcome
    Sudevan P.J., Chandrasekharan J., Sambandam S.N., Rohinikumar G.J., Annamalai S., Mounasamy V.
  8. Effects of tendon-bone healing of anterior cruciate ligament reconstruction by osteoprotegerin combined with deproteinized bovine bone
    Zou G., Song E., Wei B.
  9. Reverse shoulder arthroplasty patient personalized rehabilitation protocol. Preliminary results according to prognostic groups
    Romano A.M., Oliva F., Nastrucci G., Casillo P., Di Giunta A., Susanna M., Ascione F.
  10. Reverse total shoulder versus angular stable plate treatment for proximal humeral fractures in over 65 years old patients
    Giardella A., Ascione F., Mocchi M., Berlusconi M., Romano A.M., Oliva F., Maradei L.
  11. Normal microscopic architecture of acetabular labrum of hip joint: a qualitative original study with clinical aspects
    Kapetanakis S., Gkantsinikoudis N., Dermon A., Kommata V., Papathanasiou J., Soukakos P., Dermon C.
  12. Effects of hip flexion angle on surface electromyographic activity of the biceps femoris and semitendinosus during isokinetic knee flexion
    Kellis E., Galanis N., Kofotolis N., Hatzi A.
  13. Functional leg length discrepancy between theories and reliable instrumental assessment: a study about newly invented NPoS system
    Mahmoud A., Abundo P., Basile L., Albensi C., Marasco M., Bellizzi L., Galasso F., Foti C.
  14. Characterising the proximal patellar tendon attachment and its relationship to skeletal maturity in adolescent ballet dancers
    Rudavsky A., Cook J., Magnusson S.P., Kjaer M., Docking S.
  15. The Royal London Hospital Test for the clinical diagnosis of patellar tendinopathy
    Maffulli N., Oliva F., Loppini M., Aicale R., Spiezia F., King J.B.
  16. Reliability of a device for the knee and ankle isometric and isokinetic strength testing in older adults
    Bergamin M., Gobbo S., Bullo V., Vendramin B., Duregon F., Frizziero A., Di Blasio A., Cugusi L., Zaccaria M., Ermolao A.
  17. Ultrasound guided injection of a painful knee osteoarthritis with medial meniscus extrusion: a case series study
    Di Sante L., Venditto T., Ioppolo F., Paoloni M., Mangone M., Alviti F.
  18. Percutaneous release of the plantar fascia. New surgical procedure
    Oliva F., Piccirilli E., Tarantino U., Maffulli N.
  19. Endoscopic Flexor Halluces Longus transfer for Chronic Achilles Tendon rupture - technique description and early post-operative results
    Baumfeld D., Baumfeld T., Figueiredo A.R., de Araujo Junior L.F., Macedo B., Alves Silva T.A., Raduan F., Nery C.
  20. Triceps surae elasticity modulus measured by shear wave elastography is not correlated to the plantar flexion torque
    Lima K., Martins N., Pereira W., Oliveira L.
  21. Soft tissue pseudotumours: a pictorial review with emphasis on MRI
    Perdikakis E., Tsifountoudis I., Kalaitzoglou I., Rountas C., Malliaropoulos N., Maffulli N.
  22. Perivascular Adductor Longus muscle injury: Ultrasound and Magnetic Resonance Imaging findings
    Mattiussi G., Baldassi P.T., Pasta G., Burani A., Moreno C.
  23. Efficacy and safety of hyaluronic acid (500-730kDa) Ultrasound-guided injections on painful tendinopathies: a prospective, open label, clinical study
    Fogli M., Giordan N., Mazzoni G.
  24. Failed synthetic graft after acute Achilles tendon repair
    Mohmed A., Oliva F., Nardoni S., Maffulli N.
Last Viewed articles: la lista degli ultimi x visitati.
  1. Stem cell research and clinical development in tendon repair
    Filomeno P., Dayan V., Tourino C.
credits