MLTJ Muscles, Ligaments and Tendons Journal CIC Edizioni Internazionali 2014 January-March; 4(1): 85–89. ISSN: 2240-4554
Published online 2014 May 8.

Description of a standardized rehabilitation program based on sub-maximal eccentric following a platelet-rich plasma infiltration for jumper’s knee

Jean-François Kaux,1 Bénédicte Forthomme,2 Marie-Hélène Namurois,2 Philippe Bauvir,2 Nathalie Defawe,2 François Delvaux,2 Cédric Lehance,2 Jean-Michel Crielaard,1 and Jean-Louis Croisier2

1Physical Medicine and Sports Traumatology Department, University and University Hospital of Liège, Belgium
2Physiotherapy Service, Department of Motility Sciences, University and University Hospital of Liège, Belgium

Corresponding author: Jean-François Kaux, Physical Medicine and Sport Traumatology, University Hospital of Liège, Avenue de l’Hôpital, B35, 4000 Liège, Belgium, E-mail:


Different series emphasized the necessity of rehabilitation program after infiltration of platelet-rich plasma (PRP) in case of tendinopathy. However, most of them describe only briefly the reeducation protocol and these programs vary. Our aim was to extensively describe a specific standardized rehabilitation program.

After a review of literature of post-PRP infiltration protocols, we had developed a standardized rehabilitation protocol. This protocol was evaluated by 30 subjects with chronic jumper’s knee who. A standardised progressive sub-maximal eccentric program supervised by a physical therapist for 6 weeks was started 1 week post-infiltration. The patient benefited also from electromyostimulation, isometric strengthening and stretching of the quadriceps, cycloergometer and cryotherapy. After the supervised program, the patient had to make an auto-reeducation added to the reathletisation protocol for 6 more weeks which was followed by maintenance exercises up to 1 year. The assessments were made using a VAS, IKDC and VISA-P scores.

The VAS, IKDC and VISA-P scores decreased very significantly with time. The compliance to auto-reeducation was good.

We proposed a simple and efficient protocol based on sub-maximal eccentric reeducation to add to PRP infiltrations in case of patellar tendinopathy.

Keywords: jumper’s knee, eccentric exercises, platelet-rich plasma, PRP, rehabilitation, protocol


One quarter of athletes treated for a knee injury is diagnosed with tendinopathy. The most common knee disorder is jumper’s knee, especially among jumping sports like volleyball and basketball1. Moreover, these conditions remain often rebel to conservative management including eccentric reeducation and shock wave therapy1. Injections of platelet-rich plasma (PRP) are used for tendinopathy with the aim of providing cellular and humoral mediators to induce healing in areas of degeneration2. PRP is prepared from autologous whole blood, which is centrifuged to concentrate platelets in plasma2. The intention is to augment the natural healing process at the site of pain through the action of growth factors (GFs) (PDGF, IGF-1, VEGF, bFGF, TGF-β 1, EGF...) to promote matrix synthesis and wound healing3. Moreover, it has been demonstrated on rat tendons that a mechanical stimulation optimise the healing process of a tendon after PRP use4. It has also been demonstrated on rats, that eccentric training is more efficient than concentric training to improve tendon biomechanical properties5. Moreover, this mechanical stimulation should initiate as soon as possible after PRP infiltration because platelet stimulates especially the early phases of tendon healing process3, 4. Among human, different series emphasized the necessity of rehabilitation program after the infiltration of PRP to improve the efficacy of this treatment6. However, most of the studies describe only briefly the reeducation protocol and these programs vary a lot between themselves6. Based on literature and our clinical experience, we developed a standardized, post-PRP infiltration, sub-maximal eccentric program7.

Material and methods

Literature analysis
The electronic databases Medline and Scopus were searched (until March 31, 2014). Selected literature was limited to original articles and to English and French language peer-reviewed journals. The keywords and their synonyms used have allowed for a systematic research. We used existing MeSH (Medical Subject Heading) alone or in combination. They consisted of synonyms for “platelet-rich plasma”, “growth factors” and “patellar tendinopathy”. Studies with a high level of evidence were considered preferentially. As it is a recent treatment, there are currently few studies with a high level of evidence. Therefore, articles with a low level of evidence were also included in this review of the literature.

Our rehabilitation protocol

Rehabilitation program. After 5 to 7 days of relative rest (after the infiltration of PRP), while they could have a little local inflammatory reaction with increase of pain, they started a standardised progressive sub-maximal eccentric program supervised by a physical therapist, three times a week, for 6 weeks (Tab. 1). The eccentric exercise was realized using the weight of the patient’s body. The patient started with the back against the wall. On the pathological leg (the left side in this case), he would then slide slowly his back down the wall until his leg would be bent at a certain angle. Next, he had to push on both legs to return to the starting position. The angulation and the number of sessions were progressively increased during the reeducation, respectively from 45° to 60° and 90° and from 3 to 5 sessions of 15 to 20 repetitions, following the Stanish criteria8. In case of no pain, after 6 weeks, eccentric exercises would be done on a decline board of 25°9. Thirty seconds of rest were allowed between the sessions.

Table 1.Table 1.
Post-infiltration physical therapy program.

The patient benefited also from isometric strengthening (e.g. quadriceps drill) and passive stretching of the quadriceps, 20 minutes of electromyostimulation (50Hz), and 10 minutes of cryotherapy. Ten minutes of cycloergometer with low resistance were also added to the program after 2 post-infiltrative weeks. After the supervised program, the patient had to make an auto-reeducation added to the reathletisation protocol for 6 more weeks which is followed by maintenance exercises (2 times a week) up to 1 year.

Outcome measurements. The assessments were made using different scores as in our previous studies7:

  • - 10-point Visual Analogic Scale (VAS);
  • - International Knee Documentation Committee form (IKDC);
  • - Victorian Institute of Sport Assessment - Patellar questionnaire (VISA-P).

The whole evaluation was made before the infiltration of PRP, 6 weeks, 3 months and 1 year after the injection of PRP.

The mean score of compliance with the auto-reeducation was calculated using a scale from 0 (no compliance) to 10 (maximum compliance).

Statistics. Results were expressed as the mean ± standard deviation of the mean (SD). Changes over time were assessed using generalised linear mixed models (GLMM). Pearson correlation coefficients were used to assess the relationship between changes in various outcomes. Statistical analyses were done with the software Statistical Analysis System, version 9.1 (SAS Institute, Caro, NC) and a level of significance was set at 1%.

This study meets the ethical standards of the journal10.


Literature results
A total of 12 articles were selected7, 1121. The post-infiltrative of the protocol of all these studies included reeducation or exercises programs. Most of them (8/12) recommended eccentric exercises7, 1117. The other (3/12) recommended only stretching and isometric and isotonic strengthening programs1820. One series did not describe the rehabilitation protocol at all21. From the 12 selected series, only 3 studies described more extensively their post-infiltrative rehabilitation protocol7, 15, 16. The delay before starting exercises or rehabilitation vary a lot among series (from 24 hours to 1 month).

Noticed that many different techniques of PRP preparation were used leading to different PRP concentrations22.

Results of our rehabilitation protocol
The VAS decreased very significantly with time (p<0.0001), from 5.8 ± 1.6 before infiltration to 3.3 ± 2.4 at 6 weeks, 2.5 ± 2.3 at 3 months, and 1.4 ± 2.3 at 1 year (Fig. 1a).
Figure 1.Figure 1.
Results for the VAS, IKDC and VISA-P scores before infiltration, after 6 weeks, 3 months and 1 year. * p<0.001.

The IKDC score increased very significantly with time (p<0.0001), from 48.5 ± 11.9 before infiltration to 58.7 ± 19.3 at 6 weeks, 60.5 ± 19.6 at 3 months, and 76.9 ± 19.5 at 1 year (Fig. 1b).

The VISA-P score increased very significantly with time (p=0.0002), from 47.3 ± 16.0 before infiltration to 59.0 ± 21.0 at 6 weeks, 64.3 ± 21.5 at 3 months, and 74.3 ± 20.1 at 1 year (Fig. 1c).

The compliance to auto-reeducation was 76.4 ± 16.2% (7.64 ± 1.62/10).


Eccentric training appears to be indispensable in the treatment of tendinopathies. Animal and clinical studies have demonstrated their interest5, 23. Up to now, the gold standard to deliver such exercise remain on an isokinetic dynamometer24. Different isokinetic protocols have been developed25. This one allows to control the speed of the movement, the intensity of the contraction and the tendino-muscular stretching, and permits to have a better control of the reeducation. However, the accessibility of such dynamometer remains difficult. This is why non isokinetic rehabilitation protocols are developed.

After an intratendinous infiltration of PRP, it seems admitted that a reeducation protocol is necessary to improve the efficacy of this treatment6. However, up to now, these protocols were only succinctly or not described in the methods of the study. Moreover, these protocols vary a lot, even if eccentric exercises are generally prescribed. Only 3 papers described more extensively their reductive protocol7, 15,16 and from which one paper widely explain the post-infiltrative protocol of exercises16. This one is supervised during 3 months by a physical therapist and included eccentric exercises only after 1 month post-infiltration. However, due to limitation of the number of physiotherapy sessions by the Belgian National Institute for Health and Disability Insurance to 18 per year for a tendinopathy, our protocol had to be more accelerated followed by an auto-reeducation period.

Our protocol is based on sub-maximal eccentric reeducation under the pain threshold as recommended by Stanish8. Indeed, it was demonstrated that eccentric exercises are more efficient to improve tendon structure than concentric5. It is very important that these exercises should be carry out under the pain threshold with a VAS below or equal to 2/10 (during warming-up, during and after exercises) to avoid new tendon lesions and compromise the healing process1, 26. For this reason, first sessions were performed on the flat floor, the knee never exceeding the tip of the toes. Like that, constraint on the tendon, and also on the patella, are lesser than on a decline board27. However, after 6 weeks, in case of absence of pain, exercises could be done on a decline board of 25°, knee bend at 60° maximum, the knee never exceeding the tip of the toes, to avoid too many pression on patella and tendon9. The exercises are progressively intensified in angulation and repetitions, but in case of pain, protocol return back the following step. This protocol is supervised by a physical therapist during 6 weeks (3 times a week), during which time patient learns exercises for its auto-reeducation (3 times a week for 6 other weeks) which is followed by maintenance exercises (2 times a week) up to 1 year. During reathletisation, eccentric exercises would not been done on the decline board but on flat floor as warm-up exercises (3 sessions of 15) before specific training. The compliance was good for the majority of the patients. Indeed, we explained to subjects that the healing process is initiated after the 6 first weeks but it could continue up to 6 or 12 months as observed clinically, and it is a necessity to follow supervised reeducation by an auto-reeducation.

It was demonstrated that a 24-week eccentric program on a decline board and, after 4 weeks, on an unstable surface with extra load was efficient for young volleyball players with patellar tendinopathy28. However, we thought that these instable exercises were too constraining after an infiltration of PRP, but proprioception was done separately after the fourth week after infiltration. Nevertheless, our eccentric program on flat floor showed a greater number of repetitions and bending knees up to 90°.

Each stage of the protocol must be performed under the pain threshold (VAS equal or below 2/10). The reathletisation could be initiated after the supervised physical therapy program (after 6 weeks), one more time under the pain threshold.

Even, if there is no general agreement, we observed in our previous study that 3 months could be a cut-off period to assess the efficacy of an infiltration of PRP7. In case of partial clinical improvement, a second infiltration could be realized or a surgical option could be discussed in case of the absence of improvement.

We demonstrated in our previous study that patients had often a weakness of the quadriceps (in concentric at 60°/s as observed by isokinetics)7. Therefore isometric strengthening of this muscle associated to electromyostimulation was performed too. After each reeducation session, and later after sports activities, a local cryotherapy was recommended29. This one could be initiated with a taping or bracing to protect the tendon30.

The compliance of the auto-reeducation protocol was relatively good with more than 75%, and was similar to the other study16. To improve the compliance, this auto-reeducation protocol was easy to perform at home or as the warm-up of the reathletisation protocol, required little time and was learned with the physiotherapist.

In this study, we did not made any functional evaluation or imagery because, these parameters never change significantly in our previous study while VAS and algo-functional scores (IKDC and VISA-P) were significantly improved7.

This study is based on the patellar tendon. However, even if we did not evaluate them in a clinical protocol, we adapted this standard sub-maximal protocol to epicondylitis, epitrochleitis and Achilles tendinopathi -es with good clinical results, over more than 250 tendon infiltrations of PRP.


Based on literature and our clinical experience, we developed reeducative protocol based on sub-maximal eccentric exercises added to PRP infiltrations in case of patellar tendinopathy. This 6-weeks reeducative protocol supervised by a physical therapist must be followed by an auto-reeducation during reathletisation. After, maintenance exercises must be performed up to one year. This protocol is simple and allows a good compliance, but to confirm it’s real efficiency, it should be useful to compare it to another one.


This study was supported by the Lejeune-Lechien Foundation and ADEPS Funds (associated foundation of the Léon Frédéricq Funds).

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