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Bone morphogenetic protein signaling in rotator cuff muscle atrophy and fatty infiltration

Liu X., Joshi S., Ravishankar B., Laron D., Kim H.T., Feeley B.T.
Original Article, 113 - 119
doi: 10.11138/mltj/2015.5.2.113
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Abstract
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Background: reduced mass (atrophy) and increased fat content (fatty infiltration) of rotator cuff muscles are common complications of large or massive rotator cuff (RC) tears, and are believed to be irreversible even after tendon repairs.
Clinically, both muscle atrophy and fatty infiltration are important factors contributing to poor functional outcomes after tendon repairs. The molecular mechanism of RC muscle atrophy and FI remains undefined. In this study, we investigated
the role of bone morphogenetic proteins (BMP) signaling in RC muscle atrophy and fatty infiltration using a rat model.
Methods: unilateral massive RC tears was induced in adult rats. RC muscles were harvested at 2 and 6 weeks after injury for BMP signaling analysis. In a separate experiment, BMP inhibitor (LDN-193189) was injected to rats through daily intraperitoneal injection. RC muscles from rats in the treated and control groups were harvested at 6 weeks after injury for biochemistry and histology analysis.
Results: we found significantly increased BMP-14 and BMP-7 expression in rotator cuff muscles after RCT. Inhibiting BMP signaling resulted in increased muscle atrophy and reduced fatty infiltration in rotator cuff muscle after RC tears.
Conclusion: this result suggests that BMP signaling inhibits RC muscle atrophy but promotes fatty infiltration.
KEY WORDS: atrophy, BMP, fatty infiltration, muscle, rotator cuff tear.

Vol. 5 (No. 2) 2015 April/June

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  5. Influence of a lower leg brace on traction force in healthy and ruptured Achilles tendons
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  6. Clinical assessment is sufficient to allow outcome evaluation following surgical management of Achilles tendon ruptures
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  7. High volume image-guided injections and structured rehabilitation improve greater trochanter pain syndrome in the short and medium term: a combined retrospective and prospective case series
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  9. Platelet-rich plasma as a treatment for chronic patellar tendinopathy: comparison of a single versus two consecutive injections
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  10. The molecular systemic and local effects of intratendinous injection of Platelet Rich Plasma in tendinosis: preliminary results on a rat model with ELISA method
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    doi: 10.11138/mltj/2015.5.2.099
  11. Muscle atrophy and fatty infiltration after an acute rotator cuff repair in a sheep model
    Luan T., Liu X., Easley E.T., Ravishankar B., Puttlitz C., Feeley B.T.
    doi: 10.11138/mltj/2015.5.2.106
  12. Bone morphogenetic protein signaling in rotator cuff muscle atrophy and fatty infiltration
    Liu X., Joshi S., Ravishankar B., Laron D., Kim H.T., Feeley B.T.
    doi: 10.11138/mltj/2015.5.2.113
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  16. Letter to the editor: Platelet-rich plasma treatment improves outcomes for chronic proximal hamstring injuries in an athletic population
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  17. Obituary – Dr. Dan the Marathon Man. Requiescat in Pace. Dr. Dan Tunstal Pedoe, 30 December 1939-13 February 2015
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  1. Bone morphogenetic protein signaling in rotator cuff muscle atrophy and fatty infiltration
    Liu X., Joshi S., Ravishankar B., Laron D., Kim H.T., Feeley B.T.
    doi: 10.11138/mltj/2015.5.2.113
  2. The molecular systemic and local effects of intratendinous injection of Platelet Rich Plasma in
    tendinosis: preliminary results on a rat model with ELISA method
    Dallaudiere B., Louedec L., Lenet M.P.J., Pesquer L., Blaise E., Perozziello A., Michel J.B., Moinard M., Meyer P., Serfaty J.M.
    doi: 10.11138/mltj/2015.5.2.099
  3. Muscle atrophy and fatty infiltration after an acute rotator cuff repair in a sheep model
    Luan T., Liu X., Easley E.T., Ravishankar B., Puttlitz C., Feeley B.T.
    doi: 10.11138/mltj/2015.5.2.106
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